Eastern Michigan University
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Dr. Michael Angell

Associate Professor

photo of Dr. Angell 401W Mark Jefferson Science Complex

734.487.1004

michael.angell@emich.edu

Education

B.A. Biology - Western Maryland College, 1987

Ph.D. Microbiology & Immunology - Pennsylvania State University, Milton S. Hershey Medical Center, 1993

Post-doc Training – University of Michigan, Institute of Gerontology – 1993 - 1996

Interests and Expertise

My laboratory is interested in investigating virus-host interactions in eukaryotic and prokaryotic (bacterial) cells. One of my projects investigates the role of the mouse pathogen, Mouse Adenovirus – 1 (MAV-1), in the regulation of immune control proteins on macrophage cells. MAV-1 is used as a model for Human Adenovirus infections and understanding this interaction may help understand the pathology of adenovirus infection in the young or immunocompromised. We’re seeking to understand why MAV-1 infection enhances the expression of the regulatory protein CD40 and whether such regulation influences virus replication or immune recognition. 

My lab’s second project investigates the replication of bacterial viruses (bacteriophage) in cyanobacteria (blue-green algae). Cyanobacteria of the genus Microcystis are responsible for toxin-producing nuisance blooms in freshwater lakes, including the Great Lakes. Understanding viral infection within these cells will help us understand the role of viruses in the regulation of algal blooms as well as the regulation of environmental nutrients.

 

Publications

Hopfl,R., Christensen, N.D., Angell, M.G., Kreider, J.W. 1995. Leukocyte proliferation in vitro against cottontail rabbit papillomavirus in rabbits with persisting papillomas/cancer or after regression. Arch Dermatol Res . 287: 652-658.

Gangemi, J.D., Pifisi,L., Angell, M., Kreider, J.W. 1994. HPV replication in experimental models: Effects of interferon. Antiviral Res. 24: 175-190.

Hopfl,R.M., Christensen, N.D., Angell, M.G., Kreider, J.W. 1993. Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after papilloma regression.J. Invest. Dermatol. 101:227-231.

Okabayashi, M, Angell, M.G. , Budgeon, L.R., Kreider, J.W. 1993. Shope papilloma cell and leukocyte proliferation in regressing and progressing lesions. Am.J. Pathol. 142: 489-496.

Angell, M.G., Christensen, N.D., Kreider, J.W. 1992. An in vitro system for studying the initial stages of cottontail rabbit papillomavirus (CRPV) infection. J. Virol. Methods 39: 207-216.

Courses Taught

BIO 256 Biology of Cancer

BIO 328 Introductory Microbiology

BIO 426/526 Immunobiology

BIO 428/528 General Virology

BIO 544 Tissue Culture Techniques and Methods

The Biology Department is part of the College of Arts & Sciences, 214 Pray-Harrold