Eastern Michigan University
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Dr. James VandenBosch

Professor

James VandenBosch 401C Mark Jefferson Science Complex

734.487.4432

jim.vandenbosch@emich.edu

Education

B.B.A. University of Michigan, 1971

M.S. Eastern Michigan University, 1977

Ph.D. University of Michigan, 1988

Interests and Expertise

My research interests are the molecular mechanisms of bacterial pathogenesis, concentrating on Salmonella typhimurium as a model system. We utilize a molecular genetic strategy to investigate the genes involved in the interplay between the bacterium and the host. Our work currently focuses on how the organism senses its environment in the host and, subsequently, adapts to this environment by expressing virulence traits necessary for the continued survival of the organism and the ultimate production of disease. We are using insertional mutagenesis to create gene and operon fusions that identify genes of interest and provide information on the regulation of transcription of the genes.

Publications

Zhang, L., and J. L. VandenBosch. 1994. Temperature- regulated TnphoA Fusions in Salmonella typhimurium exhibiting decreased serum-resistance include insertions in traT. Submitted to the 94th Annual Meeting of the American Society for Microbiology. Las Vegas, Nev. May 23-27, 1994.

Zhang, L., S. J. Tsai, E. Mussin, M. Liu and J. L. VandenBosch. 1992. Isolation of a temperature-regulated TnphoA insertional mutant of Salmonella typhimurium that exhibits increased serum-susceptibility. Abstracts of the 92nd Annual Meeting of the Society for Microbiology.

VandenBosch, J. L., D. R. Kurlandsky, R. Urdangaray and G. W. Jones. 1989. Evidence of coordinate regulation of virulence in Salmonella typhimurium involving the rsk element of the 95-kilobase plasmid. Infect. Immun. 57:2566-2568.

VandenBosch, J. L., D. K. Rabert, D. R. Kurlandsky and G. W. Jones. 1989. Sequence analysis of rsk, a portion of the 95-kilobase plasmid of Salmonella typhimurium associated with resistance to the bactericidal activity of serum. Infect. Immun. 57:850-857.

VandenBosch, J. L., D. K. Rabert and G. W. Jones. 1987. Plasmid-associated resistance of Salmonella typhimurium to compliment activated by the classical pathway. Infect. Immun. 55:2645-2652.

Courses Taught

BIO 258 Germs, Plagues, & Human Infections

BIO 328 Introductory Microbiology

BIO 425 General Microbiology

BIO 545 Recombinant DNA Techniques

The Biology Department is part of the College of Arts & Sciences, 214 Pray-Harrold