Eastern Michigan University
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Cory Emal, Ph.D.

L058 Mark Jefferson Science Complex

734.487.0305

cemal@emich.edu

Education

B.S., University of Nebraska, 1997
Ph.D., University of Michigan, 2003

Organic and Medicinal Chemistry; Fermentation Science

Interests and Expertise

My research interests involve the isolation, design, and synthesis of small molecule inhibitors of biological systems. My lab currently focuses on the development of inhibitors of plasminogen activator inhibitor-1 (PAI-1), a human protein implicated in thrombosis, atherosclerosis, and myocardial infarction. This project is in collaboration with Dan Lawrence’s group at the University of Michigan Medical School, and together we have successfully identified and investigated multiple novel scaffolds that have proven to be potent and specific inhibitors of PAI-1. Some of these inhibitors are related to naturally occurring polyphenolic compounds, such as those found in green tea. Currently we are working to develop analogs of these compounds that show improved characteristics in vitro.

Publications

Li, S.-H.; Reinke, A. A.; Sanders, K. L.; Emal, C. D.; Whisstock, J. C.; Stuckey, J. A.; Lawrence, D.A. “Mechanistic characterization and crystal structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1.” Proc. Natl. Acad. Sci. USA, 2013, 110, E4941-E4949. [ link to article ]

El-Ayache, N. C.; Li, S.-H.; Warnock, M.; Lawrence, D. A.; Emal, C. D. “Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1(PAI-1)” Bioorganic and Medicinal Chemistry Letters, 2010, 20, 966-970.  [ pdf ]

Cale, J. M.; Li, S.-H.; Warnock, M.; Su, E. J.; North, P. R.; Sanders, K. L.; Puscau, M. M.; Emal, C. D.; Lawrence, D. A. “Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1” Journal of Biological Chemistry, 2010, in press.  [ pdf ]

Professional Affiliation

American Chemical Society
American Society of Brewing Chemists

Courses Taught

Organic Chemistry (Chem 371-373)
Advanced Organic Chemistry (Chem 571)
Organic Spectroscopy (Chem 572)

The Department of Chemistry is part of the College of Arts & Sciences, 214 Pray-Harrold, 734.487.4344