Eastern Michigan University
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Ingo Janser, Ph.D.

501V Mark Jefferson Bldg

734.487.0086

ijanser@emich.edu

Education

M.S., Univ. of Karlsruhe, 2002
Ph.D., RWTH Aachen Univ., 2005
Postdoc, U of Calif., Berkeley, 2007

Organic Chemistry

Interests and Expertise

My research interests are the target-oriented synthesis and modification of natural and non-natural bioactive compounds with the goal to find relationships between structure and activity of the corresponding compound. The gained knowledge can be used for rational drug design. Furthermore, my research is focused on the development of novel chiral and water stable Lewis-acid catalysts for asymmetric Lewis acid catalyzed reactions in aqueous media. This Green Chemistry approach will help to reduce organic solvent waste and make Lewis-acid catalyzed reactions more environmentally benign.

Publications

Ingo Janser, Caitlyn M. Vortolomei, Ranjith K. Meka, Courtney A. Walsh, Romy F. J. Janser "Ethacrynic acid as a lead structure for the development of potent urease inhibitors" C. R. Chim. 2013, accepted for publication.

Ingo Janser, Romy Janser "Barbituric Acid-Based GABA(A) Receptor Modulators for the Treatment of Sleep Disorder and Epilepsy and as Anesthetics" in J. Dinges, C. Lamberth (Eds.) Bioactive Heterocyclic Compound Classes: Pharmaceuticals, Wiley VCH 2012.

Enoch A. Adogla, Romy F. J. Janser, Samuel S. Fairbanks, Caitlyn M. Vortolomei, Ranjith K. Meka, Ingo Janser "Selective methoxy ether cleavage of 2,6-dimethoxyphenol followed by a selective acylation" Tetrahedron Lett. 2012, 53, 11-14.

Z. Bryant, R. Janser, M. Jabarkail, M. Candelaria-Lyons, B. Romero, S. Van slambrouck, W. Steelant, I. Janser "Inhibitory Effects of Ethacrynic Acid Analogues Lacking the alpha,beta-Unsaturated Carbonyl Unit and para-Acylated Phenols on Human Cancer Cells", Bioorg. Med. Chem. Lett. 2011, 21, 912-915.

R. Janser, R. Meka, Z. Bryant, E. Adogla, E. Vogel, J. Wharton, C. Tilley, S. Van slambrouck, W. Steelant, I. Janser "Ethacrynic Acid Analogues Lacking the alpha,beta -Unsaturated Carbonyl Unit - Potential Anti-Metastatic Drugs", Bioorg. Med. Chem. Lett. 2010, 20, 1848-1850.

Professional Affiliations

American Chemical Society
German Chemical Society

Courses Taught

Organic Chemistry (371-373)

The Department of Chemistry is part of the College of Arts & Sciences, 214 Pray-Harrold