Company:        Wayne State University

A Bioinformatics Specialist (programmer) position is available immediately at the Center for Molecular Medicine and Genetics, Wayne State University. The successful candidate will advance the primate comparative genomics and RNA functional analysis fields by facilitating the discovery and functional analysis of primate-specific genes and long noncoding RNA for combined computational and experimental efforts. The position carries an extensive body of fringe benefits (detailed at
http:// www.hr.wayne.edu/tcw/benefits/index.php).

Duties:

• Perform local, automated BLAST and BLAT searches of large sequence datasets.
• Analyze UCSC Genome Database transcript-to-genome alignments to interrogate multispecies conservation of sequence and gene structure.
• Perform cDNA and EST artefact filtering and in-silico expression profiling.
• Integrate gene structure, regulation, and expression data in customized pipelines yielding novel biological insights pertinent to nonconserved and noncoding-RNA genes.
• Construct custom UCSC tracks from raw sequence and annotation files.
• Perform periodic updates of local BLAST databases and local UCSC datasets.
• Assist with custom expression microarray probe design and probe specificity assessments.
• Assist with analysis of microarray data.
• Assist with preparation of tables and supplementary data files for peer-reviewed publications.

Qualifications:

• Master's Degree in Bioinformatics, Computer Science, or a related field. Alternatively, Bachelor's Degree with at least one year of related work experience.
• Knowledge of UCSC Genome Browser databases and tables.
• Knowledge of local implementation and batched execution of BLASTN, megaBLAST, BLASTZ, BLAT, liftOver, and RNA secondary structure prediction programs.
• Prior experience with open-source bioinformatics (e.g. BioPerl or BioPython etc.)
• Prior experience with statistical tests commonly used in genomics applications.
• Awareness of experimental biology from college-level coursework and/or applied experience.
• U.S. CITIZENSHIP, U.S. PERMANENT RESIDENT STATUS, OR A CURRENT AND VALID AUTHORIZATION TO WORK IN THE U.S.: REQUIRED.

Contact Information:

Send CV with names of 3 references to LLIPOVICH@MED.WAYNE.EDU for immediate consideration.