Symposium Abstract

Ashley Rose Bate

Department of Biology

Involvement of p160ROCK in XEphA4 Receptor Signaling in Amphibian Embryos

XEphA4 is a cellular receptor that functions to regulate cell and tissue interactions in amphibian embryos. How the receptor achieves its effects at the cellular level is largely unknown. We are testing the hypothesis that one step in the XEphA4 signaling pathway is the inhibition of p160 Rho-associated kinase (p160ROCK). We test this hypothesis by injecting embryos with Y-27632, an inhibitor of p160ROCK, and assessing whether this treatment mimics the effects of XEphA4 signaling.

Session C — 11:30 a.m. — Faculty Lounge.