Eastern Michigan University

EVENING CLASSES CANCELED

All classes will be canceled and all non-essential offices/services will be closed at 5 p.m. on Wednesday, Dec. 13, due to the severe weather. Full details.  

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Paul Price

Assistant Professor

Paul Price photo 403B Mark Jefferson Science Complex

734.487.3315

pprice5@emich.edu

Education

B.S.  Brigham Young University, 2004
Ph.D.  Washington University in St. Louis, 2011
Postdoctoral Fellow.  University of North Carolina at Chapel Hill, (Mentor: William Goldman), 2011
Postdoctoral Fellow.  Brigham Young University (Mentor: Joel Griffitts), 2011-2016

Interests and Expertise

One large group of soil bacteria known as ‘rhizobia’ have the ability to engage with in plants in a permissive bacterial infection process on compatible host plants, leading to specialized plant root organs known as root nodules. In these root nodules, the bacteria multiple, actively invade plants cells, and differentiate into nitrogen fixing cells called bacteroids. This arrangement between the plant and bacteria will supply the plant with enough fixed nitrogen to maintain plant health in environments where nitrogen supplies are limited in the soil. In exchange for fixed nitrogen, the plant supplies rhizobia with carbon resources derived from photosynthesis. This cooperative interaction occurs in biomes worldwide and is a major driving force in terrestrial nitrogen cycling. This process is also central to the concept of crop rotation in many agriculture settings. In addition to it economic and ecological implications, this symbiotic interaction provides a wonder mechanism to study the complex interactions that are essential in inter-kingdom signaling and communication, which have been evolving for millions of years. Our goals as a laboratory are to discover and closely examine which genes allow the bacteria to communicate with its plant host and which genes that plant uses to respond to the bacteria, creating a permission infection of it roots. We primarily focus on the bacterium Sinorhizobium meliloti and its nodulating plant hosts of the genus Medicago including alfalfa. We use many molecular approaches, including transposon mutagenesis, bacterial conjugation, molecular cloning, protein biochemistry, and protein expression technology to help us better understand the pathways that drive this host-microbe interaction. 

Publications

Mohammed Shabab, M.F. Arnold, J. Penterman, A.J. Wommack, H. Bocker, P.A. Price, J.S. Griffitts, E. M. Nolan and G.C. Walker. (2016) “Disulfide crosslinking influences symbiotic activities of nodule peptide NCR247.” Proceedings of the National Academy of Sciences. 113:10157-10162

Price, P.A., H.R. Tanner, B.A. Dillon, M. Shabab, G.C. Walker, J.S. Griffitts. (2015) “Rhizobial peptidase HrrP cleaves host-encoded signaling peptides and mediates symbiotic compatibility.” Proceedings of the National Academy of Sciences. 112:15244-15249.

Stasulli, N.M., K.R. Eichelberger, P.A. Price, R.D. Pechous, S.A. Montgomery, J.S. Parker, W.E. Goldman. (2015) Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague. mBio 6(5):e01530-15

Lathem, W.W., A.A. Schroeder, L.E. Bellows, J.T. Ritzert, J.T. Koo, P.A. Price, A.J. Caulfield, W.E. Goldman. (2014) Posttranscriptional regulation of Yersinia pestis cyclic AMP receptor protein Crp and impact on virulence. mBio, 5(1):e01038-13.

Pechous, R.D., V. Sivaraman, P.A. Price, N.M. Stasulli, W.E. Goldman. (2013) Early Host Targets of Yersinia pestis During Primary Pneumonic Plague. PLOS Pathogens, 9(10):e1003679.

Price, P. A., J. Jin, and W.E. Goldman. (2012) Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation. Proceedings of the National Academy of Sciences, 109: 3083-3088.

Weening, E.H., J.S. Cathelyn, G. Kaufman, M.B. Lawrenz, P.A. Price, W.E. Goldman, V.L. Miller. (2011) The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background. Infection and Immunity, 79:644-652.

Bobrov, A.G., O. Kirillina, D.A. Ryjenkov, P.A. Price, J.D. Fetherson, D. Mack, W.E. Goldman, M. Gomelsky, R.D. Perry. (2011) Systemic analysis of cyclic di-GMP signaling enzymes and their role in biofilm formation and virulence in Yersinia pestis. Molecular Microbiology, 79:533-551.

Lathem, W.W., P.A. Price, V.L. Miller, W.E. Goldman. (2007) A plasminogen-activating protease specifically controls the development of primary pneumonic plague. Science, 315:509-13.

Gravekamp, C., R. Sypniewska, S. Gauntt, M. Tarango, P. Price, R. Reddick. (2004) Behavior of metastatic and nonmetastatic breast tumors in old mice. Experimental Biology and Medicine, 229:665-75. 

Courses Taught

BIO 328 Microbiology for Health Professions

The Biology Department is part of the College of Arts & Sciences, 214 Pray-Harrold