Eastern Michigan University

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James Hoeschele, Ph.D.

Adjunct Faculty

L003 Mark Jefferson Science Complex


[email protected]


Interests and Expertise


1.   “Revisiting [PtCL2(cis-1,4-DACH)]: An Underestimated Antitumor Drug

      with Potential Application to the Treatment of Oxaliplatin-Refractory

      Colorectal Cancer”, J. Med. Chem., , 55 (16), 7182-7192(2012). Nicola

      Margiotta, Cristina Marzano, Valentina Gandin, Domenico Psella, Maruo

      Ravera, Emanuele Petruzzella , James D. Hoeschele, and Giovanni Natile,

 2.  “Biography of Dr. Barnett Rosenberg” 

        Anticancer Res. 34 (1) 417-421 ( 2014)

 3. “Serendipity and the Prepared Mind; The Discovery of the Antitumor

      Drug, Cisplatin”,  J. Inorg. Biochem. (Submitted, 1/14)

 4. “Pre-clinical Characterization of STAT3 Small Molecule Inhibitors for

     Primary and Metastatic Brain Cancer Therapy”.  J. Biol. Chem., Hikmat

     Assi, Chris  Paran, Jon Savakus, James D. Hoeschele, Nathan  VanderVeen1,

     Robert Doherty, Henry Appelman, Leda Raptis, Tom Mikkelsen,

     Pedro R  Lowenstein and Maria G Castro. (To be submitted, 2/14).

 5. Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin

     and Other Platinum Complexes .

     Matthew D. Hall, Katherine A. Telma, Ki-Eun Chang, Tobie D. Lee, John

     Lloyd, Ian G., James D. Hoeschele (S ubmitted, 1/27/14)

  6. “Microwave-Assisted Synthesis of Cisplatin”, with Cristian Chirosca

      and Emanuele Petruzzella, ( In Preparation )

 7. "Unique Reactivity of Kiteplatin with S-donor Biomolecules and DNA

      Models.". (with  Emanuele Petruzzella, Nicola Margiotta, and Giovanni

       Natile)(to be submitted to J. Biol. Chem., 2/14)

PATENT (Provisional)- March 15, 2013

  “Method of Treating Colorectal Cancer”, filed March 15, 2013.  A formal

   patent application will be submitted on or by March 15, 2014.

   (in collaboration with two research groups from Italy)



Chemistry 115, 2011

Chemistry 116 , 2011 (long-term substitute)

The Department of Chemistry is part of the College of Arts & Sciences, 214 Pray-Harrold