Eastern Michigan University

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Tod P. Holler, Ph.D.

Part-Time Lecturer

Dr. Tod Holler 501A Mark Jefferson Science Complex


[email protected]


B.S. Harvey Mudd College, 1978
Ph.D. University of Washington, 1989
Postdoctoral Fellow, Massachusetts Institute of Technology, 1989-1991

Interests and Expertise

Organic Chemistry and Enzymology

Industrial Experience
Parke-Davis Pharmaceutical Research, Ann Arbor, MI, 1991-2000
Pfizer Global Research and Development, Ann Arbor, MI, 2000-2007
Pfizer Global Research, Sandwich, UK, 2007-2010


Mosberg, JA, Yep A, Meredith TC, Smith S, Wan, P-F. Holler TP, Mobley HLT, Woodard RW. A Unique Arabinose 5-Phosphate Isomerase Found within a Genomic Island Associated with the Uropathogenicity of Escherichia coli CFT073. Journal of Bacteriology 2011;193:298-2988.

Oduor RO, Ojo KK, Williams Gareth P, Bertelli F, Mills J, Maes L, Pryde DC, Parkinson, T, Van Voorhis WC, Holler TP. Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. PLOS Neglected Diseases 2011;5(4):e1017.

Gabrielli L, Merlo S, Airoldi C, Sperandeo P, Gianera S, Polissi A, Nicotra F, Holler TP, Woodard RWCipolla L. Arabinose 5-phosphate isomerase as a target for antibacterials design: Studies with substrate analogues and inhibitors. Bioorgic and Medicinal Chemistry 2014;22(8):2576-2583.

Li C, Li W, Holler TP, Gu Z, Li Z. Polyethylene glycols enhance the thermostability of -cyclodextrin glycosyltransferase from Bacillus circulans. Food Chemistry 2014;164;17-22.

Li Z, Huang M, Gu Z, Holler TP, Cheng L, Hong Y, Li C. Asp577 mutation enhance the catalytic efficiency of cyclodextrin glycosyltransferase from Bacillus circulans.  Int J Biol Macromol 2016; 83:111-116.

Professional Affiliations

American Chemical Society
American Society for Biochemistry and Molecular Biology
American Medical Writers Association

Courses Taught

General Chemistry I (Chem 121)
General Chemistry Laboratory (Chem 122)
Fundamentals of Organic and Biochemistry (Chem 120)
Organic Chemistry Laboratory (Chem 271)

The Department of Chemistry is part of the College of Arts & Sciences, 214 Pray-Harrold