John Carbone

A photo of John Carbone

Professor

Health Sciences

312 Marshall

734.487.3303

[email protected]

Education

  • Ph.D., Nutritional Sciences, University of Connecticut
  • BS, Biochemistry, Union College

Biography

Dr. John Carbone was destined to be a nutritional scientist.  Growing up in the pristine beauty of Fort Kent, Maine, his dad would tend their multiple organic garden plots while his mom coordinated co-op deliveries of bulk wheat berries that she would grind for flour; all while a young John ran around in an “I’m Organically Grown” t-shirt.

After receiving an exceptional education in the Fort Kent school system, John earned his Bachelor’s degree in Biochemistry, with highest honors, from Union College (Schenectady, NY). He gained research experience at the University of Florida’s Whitney lab, under the tutelage of Dr. Barbara Anne-Battelle and Karen Kempler, and Harvard Medical School, as a member of Dr. Donald Coen’s lab. John then joined Dr. Nancy Rodriguez’s team at the University of Connecticut, earning his doctorate in Nutritional Sciences with concentrations in Molecular & Cellular Biology and Educational Psychology.

John joined the EMU faculty in 2009 and has spent the ensuing years engaging with students in and out of the classroom. He is also an active member of the American Society for Nutrition, serving in various capacities within the Energy and Macronutrient Metabolism Research Interest Section.

Scholarly/Research Interests

Dr. Carbone's research focuses on the role of diet and exercise in maintaining skeletal muscle integrity. Specifically, he's interested in how energy balance and dietary modifications regulate the activities of intracellular muscle protein breakdown pathways.  The bulk of these efforts are conducted in collaboration with researchers at the U.S. Army Research Institute of Environmental Medicine.

Publications

See Dr. Carbone's full Curriculum Vitae [PDF].

Gwin JA, Church DD, Hatch-McChesney A, Howard EE, Carrigan CT, Murphy NE, Wilson MA, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study. Clin Nutr. 2020: S0261-5614(20)30384-8.

Carbone JW and Pasiakos SM. Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit. Nutrients. 2019; 11(5) pii: E1136.

Carbone JW, McClung JP, Pasiakos SM. Recent advances in the characterization of skeletal muscle and whole-body protein responses to dietary protein and exercise during negative energy balance. Adv Nutr. 2019; 10(1):70-79

Margolis LM*, Carbone JW*, Berryman CE, Carrigan CT, Murphy NE, Ferrando AA, Young AJ, Pasiakos SM. Severe energy deficit at high-altitude inhibits skeletal muscle mTORC1-mediated anabolic signaling without increased ubiquitin proteasome activity. FASEB J. 2018 Jun 7:fj201800163RR. [*co-first authors, LMM & JWC contributed equally]

Berryman CE, Young AJ, Karl JP, Kenefick RW, Margolis LM, Cole RE, Carbone JW, Lieberman HR, Kim I-Y, Ferrando AA, Pasiakos SM. Severe negative energy balance during 21 d at high altitude decreases fat-free mass regardless of dietary protein intake: a randomized controlled trial. FASEB J. 2018; 32(2):894-905.

Pasiakos SM, Berryman CE, Carrigan CT, Young AJ, Carbone JW. Muscle Protein Turnover and the Molecular Regulation of Muscle Mass during Hypoxia. Med Sci Sports Exerc. 2017; 49(7):1340-1350.

Pastore RL, Brooks JT, Carbone JW. Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations. Nutr Res. 2015 Jun;35(6):474-9.

Carbone JW, Margolis LM, McClung JP, Cao JJ, Murphy NE, Sauter ER, Combs GF, Young AJ, Pasiakos SM. Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis. FASEB J. 2013; 27(12):5104-11.

Pasiakos SM, Cao JJ, Margolis LM, Sauter ER, Whigham LD, McClung JP, Rood JC, Carbone JW, Combs GF Jr, Young AJ. Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial. FASEB J. 2013; 27(9):3837-47.

Carbone JW, McClung JP, Pasiakos SM. Skeletal muscle responses to negative energy balance: Effects of dietary protein. Adv Nutr. 2012; 3:119-126.

Courses

Dr. Carbone teaches a variety of courses within the Dietetics and Human Nutrition program, including:

  • DTC 203, Nutrition for Health Professionals

  • DTC 302, Macronutrient Metabolism

  • DTC 435, Seminar in Dietetics

  • DTC 500, Research Design and Methods

  • DTC 504, Sports Nutrition

  • DTC 618, Advanced Topics in Nutrition

Professional

Awards

  • Ronald W. Collins Distinguished Faculty Award, Research II (2019)

  • Everett L. Marshall Award for Faculty Excellence in Scholarly Activity (2013, 2019)

  • Everett L. Marshall Award for Faculty Excellence in Teaching (2014)

  • Oak Ridge Institute for Science and Education Faculty Research Fellowship (2016, 2017)

  • U.S. Army Medical Research and Materiel Command (USAMRMC) recognition for research resulting in Carbone et al. FASEB J. 2013 as the #1 In-House Independent Laboratory (ILIR) funded project (2011-13)



Interests

Dr. Carbone's research focuses on the role of diet and exercise in maintaining skeletal muscle integrity. Specifically, he's interested in how energy balance and dietary modifications affect the activity of the ubiquitin proteasome pathway of muscle protein breakdown.