Michael Angell

A photo of Michael Angell

Associate Professor

Biology

401W Science Complex

734.487.1004

[email protected]

Education

  • BA, Biology, Western Maryland College, 1987
  • Ph.D., Microbiology and Immunology, Pennsylvania State University, Milton S. Hershey Medical Center, 1993
  • Post-doc Training, University of Michigan, Institute of Gerontology, 1993–1996

Interests and Expertise

My laboratory is interested in investigating virus-host interactions in eukaryotic and prokaryotic (bacterial) cells. One of my projects investigates the role of the mouse pathogen, Mouse Adenovirus – 1 (MAV-1), in the regulation of immune control proteins on macrophage cells. MAV-1 is used as a model for human adenovirus infections and understanding this interaction may help understand the pathology of adenovirus infection in the young or immunocompromised. We're seeking to understand why MAV-1 infection enhances the expression of the regulatory protein CD40 and whether such regulation influences virus replication or immune recognition.
My lab's second project investigates the replication of bacterial viruses (bacteriophage) in cyanobacteria (blue-green algae). Cyanobacteria of the genus Microcystis are responsible for toxin-producing nuisance blooms in freshwater lakes, including the Great Lakes. Understanding viral infection within these cells will help us understand the role of viruses in the regulation of algal blooms as well as the regulation of environmental nutrients.

Courses

  • BIO256 Biology of Cancer
  • BIO328 Introductory Microbiology
  • BIO426/526 Immunobiology
  • BIO428/528 General Virology
  • BIO544 Tissue Culture Techniques and Methods

Publications and Presentations

  • Hopfl, R., Christensen, N.D., Angell, M.G., Kreider, J.W. 1995. Leukocyte proliferation in vitro against cottontail rabbit papillomavirus in rabbits with persisting papillomas/cancer or after regression. Arch Dermatol Res. 287: 652–658.
  • Gangemi, J.D., Pifisi, L., Angell, M., Kreider, J.W. 1994. HPV replication in experimental models: Effects of interferon. Antiviral Res. 24: 175–190.
    Hopfl, R.M., Christensen, N.D., Angell, M.G., Kreider, J.W. 1993. Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after papilloma regression. J. Invest. Dermatol. 101:227–231.
  • Okabayashi, M, Angell, M.G., Budgeon, L.R., Kreider, J.W. 1993. Shope papilloma cell and leukocyte proliferation in regressing and progressing lesions. Am. J. Pathol. 142: 489–496.
  • Angell, M.G., Christensen, N.D., Kreider, J.W. 1992. An in vitro system for studying the initial stages of cottontail rabbit papillomavirus (CRPV) infection. J. Virol. Methods 39: 207–216.