Cory Emal

A photo of Cory Emal

Professor, Fermentation Science Coordinator

Chemistry

L058 Science Complex

734.487.0305

[email protected]

Education

  • BS, University of Nebraska, 1997
  • Ph.D., University of Michigan, 2003
  • Organic and Medicinal Chemistry, Fermentation Science

Interests and Expertise

My research interests involve the isolation, design, and synthesis of small molecule inhibitors of biological systems. My lab currently focuses on the development of inhibitors of plasminogen activator inhibitor-1 (PAI-1), a human protein implicated in thrombosis, atherosclerosis, and myocardial infarction. This project is in collaboration with Prof. Daniel Lawrence's group at the University of Michigan Medical School, and together we have successfully identified and investigated multiple novel scaffolds that have proven to be potent and specific inhibitors of PAI-1. Some of these inhibitors are related to naturally occurring polyphenolic compounds, such as those found in green tea. Currently we are working to develop analogs of these compounds that show improved characteristics in vitro.

Courses

  • CHEM 371-373 Organic Chemistry
  • CHEM 571 Advanced Organic Chemistry
  • CHEM 572 Organic Spectroscopy
  • FERM 101 Introduction to Fermentation Science
  • FERM 102 Introduction to Fermentation Science Laboratory
  • FERM 421 Sensory Analysis of Fermented Products
  • FERM 425 Fermented Beverage Production
  • FERM 441 Fermentation Production Facilities

Publications and Presentations

  • Migliorini, M.; Li, S.; Zhou, A.; Emal, C. D.; Lawrence, D. A.; Strickland. D. K. "High affinity binding of plasminogen-activator inhibitor 1-complexes to LDL receptor-related protein 1 requires lysines 80, 88 and 207." Journal of Biological Chemistry2019in press. [link]
  • Reinke, A. A.; Li, S.; Warnock, M.; Shaydakov, M. E.; Guntaka, N. S.; Su , E. J.; Diaz, J. A.; Emal, C. D.; Lawrence, D. A. "Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate." Journal of Biological Chemistry, 2018, in press.
  • Li, S.-H.; Reinke, A. A.; Sanders, K. L.; Emal, C. D.; Whisstock, J. C.; Stuckey, J. A.; Lawrence, D.A. "Mechanistic characterization and crystal structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1." Proc. Natl. Acad. Sci. USA, 2013, 110, E4941–E4949.
  • El-Ayache, N. C.; Li, S.-H.; Warnock, M.; Lawrence, D. A.; Emal, C. D. "Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1(PAI-1)" Bioorganic and Medicinal Chemistry Letters, 2010, 20, 966–970.
  • Cale, J. M.; Li, S.-H.; Warnock, M.; Su, E. J.; North, P. R.; Sanders, K. L.; Puscau, M. M.; Emal, C. D.; Lawrence, D. A. "Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1" Journal of Biological Chemistry, 2010, in press.

Professional Affiliations

  • American Chemical Society
  • Certified Cicerone®
  • American Society of Brewing Chemists
  • Master Brewers Association of the Americas